Victoza (liraglutide) and Byetta (exenatide) are currently used as a second line of defense to manage blood sugar levels in type 2 diabetes. These injectable drugs, usually used in combination with oral diabetes medications, are non-insulin and simulate the hormone GLP-1, which helps the pancreas release the right amount of insulin. Therefore, blood sugar levels remain closer to normal.
The Good News About Victoza
Victoza has been touted as the new wonder drug for type 2 diabetes. Injections are given once per day, regardless of food intake. The pen does not have to be refrigerated after the first dose and is easily kept in a purse or by the bedside. With adjustable dosages, users begin at the 0.6 mg level for at least one week. Producers of Victoza state that the 0.6 level is not a therapeutic level, although many people report lower fasting blood sugar levels during the first week. The dosage is adjusted based on doctor recommendations. After the 0.6 mg level, the patient dials up to the 1.8 level, and then to 2.4 mg., as directed by the doctor. A 32 gauge needle is used, so the injection is virtually pain-free. Injections are given in the stomach, thigh or upper arm.
Many patients report significant weight loss with Victoza. Apparently, Victoza suppresses the appetite and leads to eating less. Used in conjunction with exercise and diet, Victoza can possibly help with large amounts of weight loss.
...And the Bad News
The side effects of Victoza keep many patients from continuing therapy. Reports of side effects include vomiting, nausea, diarrhea and headache. These eventually decrease over time. Hives have also been reported. Approximately 13% of patients reported nausea during the first two weeks of treatment.
Victoza may also cause possible thyroid tumors. In the testing phases, the medicine in Victoza caused mice and rats to develop thyroid tumors. Therefore, Victoza should not be taken if thyroid cancer is in the family history of a patient.
Victoza is costly. Although many insurance plans cover Victoza, the copay is $100 - $150 for three pens. The cost without insurance is approximately $428 for three pens. One pen may last up to a month at the 0.6 mg dosage and less than a month at the other doses. Victoza offers a card to help save money on prescriptions. Also, pharmacies differ greatly in their prices, regardless of insurance, so it definitely pays to shop around.
The Pros of Byetta
Byetta is also a GLP-1 injectable drug that works to lower blood sugar. Results are often seen the very first day. The Byetta pen contains pre-measured doses for convenience. As with Victoza, patients often lose weight while taking Byetta. Also, the Byetta pen does not need to be stored in the refrigerator after the first use. A small needle is used for easy injections. Byetta injections are given subcutaneously in the upper thigh, stomach or upper arm. The recommended starting dose for Byetta is 5 mcg given twice per day. The dose may be eventually increased to 10 mcg twice per day.
Byetta is less expensive than Victoza. With insurance, one pen is approximately $35. Plan on paying $210 - $245 without insurance.
The Cons of Byetta
Byetta must be taken twice per day within one hour of a meal. For example, if Byetta is injected at 5:00, the patient must eat by 6:00. Follow the dosage prescribed by the doctor.
Side effects of Byetta include nausea, vomiting, diarrhea, heachache and dizziness. Most of these symptoms decrease after the first few weeks. Byetta may cause inflammation of the pancreas (pancreatitis), which could be fatal.
Make Wise Choices
It is important to work closely with a doctor to determine the best course of action for managing type 2 diabetes. Whether Victoza or Byetta is chosen, it is imperative to follow a diet and exercise plan in conjunction with appropriate medication. Byetta and Victoza are non-insulin drugs and are often used with first line drugs such as Metformin and Glucatrol. Making wise choices and taking the effects of type 2 diabetes seriously can help ensure a long, healthy life!
See also: Victoza: The New Wonder Drug for Type 2 Diabetes
Resources: www.Byetta.com
victoza.com
Disclaimer: The information contained in this article is for educational purposes only and should not be used for diagnosis or to guide treatment without the opinion of a health professional. Any reader who is concerned about his or her health should contact a doctor for advice.
Tina Halbert - Tina M. Halbert, M.Ed., NBCT
Join the Conversation